LCModel

Application:

• Automatic quantification of in vivo proton MR spectra.


• Some user applications of LCModel can be seen in the sample publications list.

News:

• Mainly water & lipids, as in vertebra.
  
  
• Water & lipids plus possibly choline, as in breast and liver.
  
  

Recent News:

• LCModel Version 6.1 (free upgrade for current LCModel sites) with new options, including analysis of muscle spectra, particularly for IMCL.
  
  
• A Linux x86 version (e.g., for PCs with Intel or AMD processors) is now available. It is extremely fast, with an excellent hardware performance/price ratio, particularly interesting for MRSI.
  
  
• In Japan, you can obtain LCModel directly from the authorized LCModel distributor, L.A. Systems, http://www.las.jp.
  
  
• Major new LCModel Version 6 (free upgrade for current LCModel sites) with many new features, including:
  
  
• Estimates of macromolecule and lipid contributions in normals and in pathologies (e.g., tumors) with strong lipid signals and without strong lipid signals.
  
  
• Analyses of full 2D slices or rectangular 2D subsets of 2D or 3D MRSI data sets.
  
  

Features:

• Fully automatic, non-interactive, operator-independent: time-domain data input, one-page summary output.
  
  
• Fully developed, over 15 years, with spectra analyzed from a wide variety of scanners and field strengths at more than 400 sites.

Download, Install & Test:

• You can freely download the complete LCMgui/LCModel package for your Linux PC or Sun, SGI or DEC/Compaq Unix workstation. (The two commands needed for installation and the run with the test data are also specified.) You can also test the preparation and input of your own data to LCModel.
  
  
• You can fully enable your LCModel package to analyze all data (not just the test data) with a license.

Methods are described in:

• S.W. Provencher: Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30, 672 (1993).


• User's Manual (you can always get the latest version here).

LCMgui Graphical User Interface

• Freely available for use with LCModel.
  
  
• Simplified usage, often only with mouse clicks, in two steps:
  1. Select the data with the File Selector;
     
  2. Start LCModel (optionally checking and modifying any settings) in the Control Window.
  
  
• Currently for the following single-voxel data:
  • Bruker ParaVision fid files (if necessary, converted by you to analog mode with Bruker's convdta).
    
  • GE 5.x Probe raw P-files and spectrum G-files.
    
  • GE Probe raw P-files, including (new) 14.0 M3 P-files. Also for P-files with multi-channel (phased-array) data.
    
  • Hitachi data: part of the Hitachi software; no need to purchase separately.
    
  • Philips SDAT & SPAR files.
    
  • Picker (later Marconi, now Philips) DUMP files.
    
  • Siemens *rda files transferred from the syngo PC console and Siemens raw files from the (old) Numaris-3 Unix console.
    
  • Toshiba rawData files and (new) Version 7.xx DICOM files;
    
  • Varian fid files;
    
  • Other data types using your own conversion script.
  
  
• Currently for the following MRSI data:
  • Bruker (analog mode), Philips, Siemens & Toshiba data, including interactive display, selection and analysis of full 2D slices or rectangular subsets. (Instructions in Sec. 3.6 of the LCModel Manual.)
    
  • Other data types using your own conversion script;
    
  • For GE MRSI (and single-voxel) data, Mary McLean's LCModel interface [MA McLean et al, Magn Reson Med 44, 401 (2000)] is integrated into GE's SAGE Research version (from SAGE Dev2002.1).